The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption. Academic Article

abstract

• Amphiphilic PEO-silanes (a-c) having siloxane tethers of varying lengths with the general formula alpha-(EtO)3Si-(CH2)2-oligodimethylsiloxane(n)-block-poly(ethylene oxide)8-OCH3 [n=0 (a), n=4 (b), and n=13 (c)] were grafted onto silicon wafers and resistance to adsorption of plasma proteins was measured. Distancing the PEO segment from the hydrolyzable triethoxysilane [(EtO)3Si] grafting group by a oligodimethylsiloxane tether represents a new method of grafting PEO chains to surfaces. Properties of surfaces grafted with a-c were compared to surfaces grafted with a traditional PEO-silane containing a propyl spacer [(EtO)3Si-(CH2)3-poly(ethylene oxide)8-OCH3, PEO control]. As the siloxane tether length increased, chain density of PEO-silanes grafted onto oxidized silicon wafers decreased and hydrophobicity of the PEO-silane increased which led to a decrease in surface hydrophilicity. Despite decreased surface hydrophilicity, resistance to the adsorption of bovine serum albumin (BSA) increased in the order: PEO control

authors

• Grunlan, Melissa

published proceedings

• Biomaterials

altmetric score

• 3

author list (cited authors)

• Murthy, R., Shell, C. E., & Grunlan, M. A.

citation count

• 56

complete list of authors

• Murthy, Ranjini||Shell, Courtney E||Grunlan, Melissa A

publication date

• January 2009

publisher

• Elsevier  Publisher

published in

• Biomaterials  Journal

keywords

• Adsorption
• Animals
• Cattle
• Fibrinogen
• Humans
• Molecular Structure
• Oxidation-Reduction
• Polyethylene Glycols
• Serum Albumin, Bovine
• Siloxanes
• Surface Properties

Digital Object Identifier (DOI)

• 10.1016/j.biomaterials.2009.01.051

start page

• 2433

end page

• 2439

volume

• 30

issue

• 13

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.biomaterials.2009.01.051