The Tombusvirus-encoded P19: from irrelevance to elegance.

abstract

• Since its discovery in the late 1980s, the status of the Tombusvirus-encoded p19 protein (P19) changed from being thought obsolete to its identification a decade later as an important viral pathogenicity factor. The recent finding that P19 suppresses RNA interference (RNAi) by appropriating short interfering RNAs led to its widespread use as an RNAi-probing tool in various plant and animal models. Here, I discuss how our knowledge of p19 has developed over the years, with emphasis on the relevance of understanding its biological roles during Tombusvirus infection of plants.

authors

• Scholthof, Herman

published proceedings

• Nat Rev Microbiol

altmetric score

• 7

author list (cited authors)

• Scholthof, H. B.

citation count

• 110

complete list of authors

• Scholthof, Herman B

publication date

• May 2006

publisher

• Springer Nature  Publisher

published in

• Nature Reviews Microbiology  Journal

keywords

• RNA Interference
• Tombusvirus
• Viral Proteins
• Virulence Factors

PubMed Central ID

• 16518419

Digital Object Identifier (DOI)

• 10.1038/nrmicro1395

start page

• 405

end page

• 411

volume

• 4

issue

• 5

URL

• http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrmicro1395