IGF2 genotype and obesity in men and women across the adult age span.
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We studied a previously reported association between the IGF2 gene's ApaI polymorphism and obesity in 500 healthy men and women (19-90 y). We hypothesized that individuals homozygous for the IGF2 A allele (A/A) would exhibit lower body mass, BMI and DEXA-measured fat mass compared to G/G homozygotes. Subjects were categorized as exhibiting the G/G (n = 241), G/A (n = 197) or A/A (n = 62) genotype. Contrary to our hypothesis, no difference was observed in body mass, body mass index (BMI) or fat mass between the G/G and A/A genotype groups in the entire cohort. Surprisingly, Caucasian A/A individuals (n = 427) exhibited significantly higher fat mass compared to Caucasian G/G individuals (P < 0.05). In summary, individuals homozygous for the IGF2 G allele do not exhibit higher body mass, BMI or fat mass compared to A/A individuals; however, Caucasians with the A/A genotype exhibit higher fat mass than G/G individuals.
Int J Obes Relat Metab Disord
author list (cited authors)
Roth, S. M., Schrager, M. A., Metter, E. J., Riechman, S. E., Fleg, J. L., Hurley, B. F., & Ferrell, R. E.
complete list of authors
Roth, SM||Schrager, MA||Metter, EJ||Riechman, SE||Fleg, JL||Hurley, BF||Ferrell, RE