Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. Academic Article uri icon


  • Interleukin-15 (IL-15) is an anabolic cytokine that is produced in skeletal muscle and directly affects muscle anabolism in animal and in vitro models. The contribution of IL-15 variability in muscle responses to 10 wk of resistance exercise training in young men and women was examined by measuring acute and chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene (IL15RA). Participants trained 3 days a week at 75% of one repetition maximum, performing three sets (6-10 repetitions) of 13 resistance exercises. Plasma IL-15 protein was significantly increased (P < 0.05) immediately after acute resistance exercise but did not change with training and was not associated with variability in muscle responses with training. A single nucleotide polymorphism in exon 7 of IL15RA was strongly associated with muscle hypertrophy and accounted for 7.1% of the variation in regression modeling. A polymorphism in exon 4 was also independently associated with muscle hypertrophy and accounted for an additional 3.5% of the variation in hypertrophy. These results suggest that IL-15 is an important mediator of muscle mass response to resistance exercise training in humans and that genetic variation in IL15RA accounts for a significant proportion of the variability in this response.

published proceedings

  • J Appl Physiol (1985)

altmetric score

  • 8.142

author list (cited authors)

  • Riechman, S. E., Balasekaran, G., Roth, S. M., & Ferrell, R. E.

citation count

  • 179

complete list of authors

  • Riechman, Steven E||Balasekaran, G||Roth, Stephen M||Ferrell, Robert E

publication date

  • December 2004