A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes(). Academic Article uri icon

abstract

  • The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2-positive and glial fibrillary acid protein-negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.

published proceedings

  • Vet Comp Oncol

altmetric score

  • 1

author list (cited authors)

  • Bentley, R. T., Burcham, G. N., Heng, H. G., Levine, J. M., Longshore, R., Carrera-Justiz, S., ... Miller, M. A.

citation count

  • 14

complete list of authors

  • Bentley, RT||Burcham, GN||Heng, HG||Levine, JM||Longshore, R||Carrera-Justiz, S||Cameron, S||Kopf, K||Miller, MA

publication date

  • September 2016

publisher