Neuroprotective Treatments for Acute Spinal Cord Injury Associated with Intervertebral Disc Herniation Chapter uri icon

abstract

  • 2015 ACVS Foundation. Medical treatments for spinal cord injury (SCI) are typically classified as neuroprotective, regenerative, or plasticity inducing. This chapter reviews modern, accepted means of developing and testing novel therapeutics. It defines commonly used outcome matrices, and further reviews published clinical trial data. Drugs that show promise in animal models-preferably in multiple studies from independent laboratories-are then taken to clinical trials. Using valid outcome measures is central to generating accurate data concerning the effect of any intervention for SCI. Polyethylene glycol (PEG) has received attention in recent years as a neuroprotective treatment for dogs with intervertebral disc herniation (IVDH)-associated SCI. The effects of PEG are believed to be mediated by the agent's ability to penetrate the central nervous system and act as a surfactant. The surfactant properties of PEG may permit fusion of transected axons and sealing of disrupted myelin.

author list (cited authors)

  • Levine, J. M.

Book Title

  • Advances in Intervertebral Disc Disease in Dogs and Cats

publication date

  • January 1, 2014 11:11 AM