Inhibition of uterine prostaglandin-F2 alpha production by bovine conceptus secretory proteins. Academic Article

abstract

• The effect of bovine conceptus secretory proteins (CSP) on uterine prostaglandin (PG)-F2 alpha production was evaluated in dairy cattle following injection of estradiol-17 beta. Intrauterine injections of dialyzed serum proteins (Control, n = 5) or CSP (n = 5) were administered from days 15 through 18 post-estrus. Following intrauterine treatments on day 18, all cows were injected with E2 (3 mg) to stimulate uterine PGF2 alpha production. Plasma concentrations of progesterone (P4) and 15-keto-13,14-dihydro-PGF2 alpha (PGFM) were determined by RIA. The PGFM responses following E2 challenge were decreased (p less than 0.01) for cows receiving CSP versus serum proteins into the uterine lumen. Individual PGFM, P4 and cycle length responses are discussed. Data suggest that proteins secreted by the bovine conceptus suppress uterine PGF2 alpha production during pregnancy recognition in the cow.

authors

• Bazer, Fuller

published proceedings

• Prostaglandins

author list (cited authors)

• Knickerbocker, J. J., Thatcher, W. W., Bazer, F. W., Barron, D. H., & Roberts, R. M.

citation count

• 30

complete list of authors

• Knickerbocker, JJ||Thatcher, WW||Bazer, FW||Barron, DH||Roberts, RM

publication date

• April 1986

publisher

• Elsevier  Publisher

published in

• Prostaglandins  Journal

keywords

• Animals
• Cattle
• Dinoprost
• Estradiol
• Female
• Luteolysis
• Pregnancy
• Pregnancy Maintenance
• Pregnancy Proteins
• Pregnancy, Animal
• Progesterone
• Prostaglandins F
• Uterus

PubMed Central ID

• 3460116

Digital Object Identifier (DOI)

• 10.1016/0090-6980(86)90180-2

start page

• 777

end page

• 793

volume

• 31

issue

• 4

URL

• http://dx.doi.org/10.1016/0090-6980(86)90180-2