MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases. Academic Article

abstract

• Activation and recruitment of resident macrophages in tissues in response to physiological stress are crucial regulatory processes in promoting the development of obesity-associated metabolic disorders and cardiovascular diseases. Recent studies have provided compelling evidence that microRNAs play important roles in modulating monocyte formation, macrophage maturation, infiltration into tissues and activation. Macrophage-dependent systemic physiological and tissue-specific responses also involve cell-cell interactions between macrophages and host tissue niche cell components, including other tissue-resident immune cell lineages, adipocytes, vascular smooth muscle and others. In this review, we highlight the roles of microRNAs in regulating the development and function of macrophages in the context of obesity, which could provide insights into the pathogenesis of obesity-related metabolic syndrome and cardiovascular diseases.

authors

• Bazer, Fuller

published proceedings

• Cells

altmetric score

• 1

author list (cited authors)

• Chang, R., Ying, W., Bazer, F. W., & Zhou, B.

citation count

• 22

complete list of authors

• Chang, Richard Cheng-An||Ying, Wei||Bazer, Fuller W||Zhou, Beiyan

publication date

• July 2014

publisher

• MDPI  Publisher

published in

• Cells  Journal

keywords

• 1 Underpinning Research
• 1.1 Normal Biological Development And Functioning
• 2 Aetiology
• 2.1 Biological And Endogenous Factors
• 32 Biomedical And Clinical Sciences
• 3208 Medical Physiology
• Biotechnology
• Cardiovascular
• Metabolic And Endocrine
• Nutrition
• Obesity
• Stroke

PubMed Central ID

• 25014161

Digital Object Identifier (DOI)

• 10.3390/cells3030702

start page

• 702

end page

• 712

volume

• 3

issue

• 3

URL

• http://dx.doi.org/10.3390/cells3030702