mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets. Academic Article uri icon

abstract

  • IL-17 mediates immune responses against extracellular pathogens, and it is associated with the development and pathogenesis of various autoimmune diseases. The expression of IL-17 is regulated by various intracellular signaling cascades. Recently, it has been shown that mechanistic target of rapamycin (mTOR) signaling, comprised mainly of mTORC1 signaling, plays a critical role in IL-17 expression. Here, we review the current knowledge regarding mechanisms by which mTORC1 regulates IL-17 expression. mTORC1 positively modulates IL-17 expression through several pathways, i.e. STAT3, -HIF-1, -S6K1, and -S6K2. Amino acids (AAs) also regulate IL-17 expression by being the energy source for Th17 cells, and by activating mTORC1 signaling. Altogether, the AA-mTORC1-IL-17 axis has broad therapeutic implications for IL-17-associated diseases, such as EAE, allergies, and colitis.

published proceedings

  • Eur J Immunol

altmetric score

  • 9.75

author list (cited authors)

  • Ren, W., Yin, J., Duan, J., Liu, G., Tan, B., Yang, G., ... Yin, Y.

citation count

  • 71

complete list of authors

  • Ren, Wenkai||Yin, Jie||Duan, Jielin||Liu, Gang||Tan, Bie||Yang, Guan||Wu, Guoyao||Bazer, Fuller W||Peng, Yuanyi||Yin, Yulong

publication date

  • February 2016

publisher