Electrospinning of silica nanochannels for single molecule detection Academic Article uri icon


  • We have fabricated silica nanochannels with inner diameter as small as 20 nm using a scanned coaxial electrospinning and demonstrated their application for single molecule detection. A coaxial jet, with the use of motor oil as the core and silica sol-gel solution as the shell, is extruded through a coaxial source and deposited on the rotating collector as oriented nanofibers. They are then annealed to cross-link silica and eliminate motor oil, thereby forming nanochannels. Subsequently, a fluorescent dye was injected into the individual nanochannels via a capillary force and single molecule detection was performed by monitoring the photon signals from 5-Iodoacetamidofluorescein. © 2006 American Institute of Physics.

author list (cited authors)

  • Wang, M., Jing, N., Su, C. B., Kameoka, J., Chou, C., Hung, M., & Chang, K.

citation count

  • 57

publication date

  • January 2006