Thiol-click chemistries for responsive neural interfaces. Academic Article

abstract

• Neural interfaces provide an electrical connection between computers and the nervous system: current penetrating devices are orders-of-magnitude stiffer than surrounding tissue. In this work, recent efforts in softening electronics and utilize thiol-ene and thiol-epoxy "click" reactions are built upon to incorporate fluid-sensitive hydrogen bonding into smart substrates for high electrode density neural interfaces. The modulus of these substrates drops more than two orders of magnitude in response to physiological conditions, despite fluid uptake of less than 6%, and can be tuned by the covalent crosslink density and degree of hydrogen bonding in the polymer network. Intracortical and intrafascicular electrode arrays are fabricated and characterized with impedance spectroscopy and cyclic voltammetry.

authors

• Maitland, Duncan
• Ware, Taylor

published proceedings

• Macromol Biosci

altmetric score

• 3.25

author list (cited authors)

• Ware, T., Simon, D., Hearon, K., Kang, T. H., Maitland, D. J., & Voit, W.

citation count

• 31

complete list of authors

• Ware, Taylor||Simon, Dustin||Hearon, Keith||Kang, Tong H||Maitland, Duncan J||Voit, Walter

publication date

• December 2013

publisher

• Wiley  Publisher

published in

• Macromolecular Bioscience  Journal

keywords

• Alkenes
• Allyl Compounds
• Animals
• Click Chemistry
• Dielectric Spectroscopy
• Electrochemical Techniques
• Epoxy Compounds
• Humans
• Hydrogen Bonding
• Mechanical Properties
• Microelectrodes
• Neural Conduction
• Polymers
• Stimuli-sensitive Polymers
• Structure-property Relations
• Sulfhydryl Compounds
• Surface Properties
• THERMOSETS
• Thin Films
• Triazines

PubMed Central ID

• 24115484

Digital Object Identifier (DOI)

• 10.1002/mabi.201300272

start page

• 1640

end page

• 1647

volume

• 13

issue

• 12

URL

• http%3A%2F%2Fdx.doi.org%2F10.1002%2Fmabi.201300272