Optofluidic device for ultra-sensitive molecule detection using surfaceenhanced Raman spectroscopy
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We have developed an optofluidic device that can significantly improve the sensitivity, efficiency and reproducibility of the surface enhanced Raman spectroscopy (SERS). This device has demonstrated the capalibity of detecting molecules of interest at ultra-low concentration and is able to identify fingerprint signals from multiple analytes. This device can potentially be used for the definitive early stage diagnostics of disease associated with protein conformation change such as Alzheimer's disease (AD) or Bovine Spongiform Encephalopathy (BSE) . © 2008 CBMS.
author list (cited authors)
Wang, M., Jing, N., Benford, M., Chou, I. H., Beier, H. T., Coté, G. L., & Kameoka, J.