Embolic applications of shape memory polyurethane scaffolds Chapter uri icon

abstract

  • 2016 Elsevier Ltd. All rights reserved. Polyurethane shape memory polymers (SMPs) have found a variety of uses in the medical industry in the form of self-tightening sutures, suture anchors, ligament fixation devices, vascular stents, and thrombectomy devices. New formulations of polyurethane SMP scaffolds are gaining significant interest for use in vascular embolization procedures. These scaffolds have demonstrated rapid time to occlusion, improved healing, and favorable biocompatibility, and they eliminate the need to implant multiple devices to achieve stable occlusion, significantly reducing procedure times and the total cost of treatment. Described here are various methods used to fabricate SMP scaffolds, indications for SMP scaffold embolization, advantages of using these scaffolds in embolization procedures, results seen in animal studies that made use of SMP scaffolds, and future directions for SMP scaffolds that will propel the technology to significant use beyond vessel occlusion.

author list (cited authors)

  • Landsman, T. L., Weems, A. C., Hasan, S. M., Thompson, R. S., Wilson, T. S., & Maitland, D. J.

citation count

  • 3

complete list of authors

  • Landsman, TL||Weems, AC||Hasan, SM||Thompson, RS||Wilson, TS||Maitland, DJ

Book Title

  • Advances in Polyurethane Biomaterials

publication date

  • February 2016