Palladium-Catalyzed, Multicomponent Approach to -Lactams via Aryl Halide Carbonylation. Academic Article

abstract

• A palladium-catalyzed multicomponent method for the synthesis of -lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(PtBu3)2 and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted -lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic -lactams in good yields and selectivity.

authors

• Bengali, Ashfaq

published proceedings

• J Org Chem

author list (cited authors)

• Torres, G. M., De La Higuera Macias, M., Quesnel, J. S., Williams, O. P., Yempally, V., Bengali, A. A., & Arndtsen, B. A.

citation count

• 27

complete list of authors

• Torres, Gerardo M||De La Higuera Macias, Maximiliano||Quesnel, Jeffrey S||Williams, Oliver P||Yempally, Veeranna||Bengali, Ashfaq A||Arndtsen, Bruce A

publication date

• December 2016

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Organic Chemistry  Journal

keywords

• 0305 Organic Chemistry

PubMed Central ID

• 27978726

Digital Object Identifier (DOI)

• 10.1021/acs.joc.6b02405

start page

• 12106

end page

• 12115

volume

• 81

issue

• 24

URL

• http://dx.doi.org/10.1021/acs.joc.6b02405