Palladium-Catalyzed, Multicomponent Approach to -Lactams via Aryl Halide Carbonylation.
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A palladium-catalyzed multicomponent method for the synthesis of -lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(PtBu3)2 and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted -lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic -lactams in good yields and selectivity.
author list (cited authors)
Torres, G. M., De La Higuera Macias, M., Quesnel, J. S., Williams, O. P., Yempally, V., Bengali, A. A., & Arndtsen, B. A.
complete list of authors
Torres, Gerardo M||De La Higuera Macias, Maximiliano||Quesnel, Jeffrey S||Williams, Oliver P||Yempally, Veeranna||Bengali, Ashfaq A||Arndtsen, Bruce A