Palladium-Catalyzed, Multicomponent Approach to -Lactams via Aryl Halide Carbonylation. Academic Article uri icon


  • A palladium-catalyzed multicomponent method for the synthesis of -lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(PtBu3)2 and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted -lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic -lactams in good yields and selectivity.

published proceedings

  • J Org Chem

author list (cited authors)

  • Torres, G. M., De La Higuera Macias, M., Quesnel, J. S., Williams, O. P., Yempally, V., Bengali, A. A., & Arndtsen, B. A.

citation count

  • 27

complete list of authors

  • Torres, Gerardo M||De La Higuera Macias, Maximiliano||Quesnel, Jeffrey S||Williams, Oliver P||Yempally, Veeranna||Bengali, Ashfaq A||Arndtsen, Bruce A

publication date

  • December 2016