Chylomicronemia elicits atherosclerosis in mice--brief report. Academic Article uri icon

abstract

  • OBJECTIVE: The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. METHODS AND RESULTS: Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins. CONCLUSIONS: Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins.

published proceedings

  • Arterioscler Thromb Vasc Biol

author list (cited authors)

  • Weinstein, M. M., Yin, L., Tu, Y., Wang, X., Wu, X., Castellani, L. W., ... Young, S. G.

citation count

  • 56

complete list of authors

  • Weinstein, Michael M||Yin, Liya||Tu, Yiping||Wang, Xuping||Wu, Xiaohui||Castellani, Lawrence W||Walzem, Rosemary L||Lusis, Aldons J||Fong, Loren G||Beigneux, Anne P||Young, Stephen G

publication date

  • January 2010