Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing. Academic Article uri icon


  • Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.

published proceedings

  • J Biomed Opt

author list (cited authors)

  • Arora, R., Petrov, G. I., Liu, J., & Yakovlev, V. V.

citation count

  • 45

complete list of authors

  • Arora, Rajan||Petrov, Georgi I||Liu, Jian||Yakovlev, Vladislav V

publication date

  • February 2011