Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing. Academic Article

abstract

• Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.

authors

• Yakovlev, Vladislav

published proceedings

• J Biomed Opt

author list (cited authors)

• Arora, R., Petrov, G. I., Liu, J., & Yakovlev, V. V.

citation count

• 45

complete list of authors

• Arora, Rajan||Petrov, Georgi I||Liu, Jian||Yakovlev, Vladislav V

publication date

• February 2011

publisher

• SPIE, the international society for optics and photonics  Publisher

published in

• Journal of Biomedical Optics  Journal

keywords

• Biosensing Techniques
• Computer-Aided Design
• Equipment Design
• Equipment Failure Analysis
• Image Enhancement
• Lasers
• Microscopy
• Nonlinear Dynamics
• Reproducibility Of Results
• Sensitivity And Specificity
• Spectrum Analysis, Raman

PubMed Central ID

• 21361677

Digital Object Identifier (DOI)

• 10.1117/1.3533317

start page

• 021114

end page

• 021114

volume

• 16

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1117%2F1.3533317