Alcohol's effects on female puberty: the role of insulin-like growth factor 1. Academic Article uri icon


  • Research suggests that alcohol consumption during early adolescence may delay the onset of female puberty. Alcohol's effect on sexual development is associated with altered function of insulin-like growth factor 1 (IGF-1). This hormone, which is produced in the liver, travels through the bloodstream to the brain, where it helps coordinate overall physical growth with the maturation of the reproductive system. Long-term alcohol consumption inhibits the production of IGF-1 in the liver. Short-term alcohol administration alters IGF-1 function within the brain, ultimately suppressing the release of specific reproductive hormones that initiate puberty. Large proportions of young girls develop drinking habits that place them at risk for alcohol-related endocrine disorders at a crucial time in female pubertal development.

published proceedings

  • Alcohol Health Res World

author list (cited authors)

  • Les Dees, W., Hiney, J. K., & Srivastava, V.

citation count

  • 6

complete list of authors

  • Les Dees, W||Hiney, JK||Srivastava, V

publication date

  • December 1998