Macrophage cytophilic antibody in mice. The relationship between the adherence of antigen to macrophages mediated by macrophage-cytophilic antibodies and opsonic adherence antibodies.
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Investigations into the fate of erythrocyte rosettes caused by cytophilic antibodies were performed. Results indicated that IgG cytophilic antibodies, after combining with sheep erythrocytes, gained properties which were not present in the uncombined antibody. These included stability of rosettes at 37 C and the ability of erythrocytes sensitized with cytophilic antibody to adhere to neutrophils. In contrast rosettes formed by the action of IgM cytophilic antibodies were unstable at 37 C and erythrocytes sensitised by IgM cytophilic antibodies did not adhere to neutrophils. Both IgM and IgG cytophilic antibodies could act as opsonins but the advantages that cytophilic antibodies possess over other mechanisms of opsonisation are not obvious. 1970 S. Karger AG, Basel.
