Cell-mediated hypersensitivity in rabbits infected with Trypanosoma brucei and Trypanosoma rhodesiense. Academic Article

abstract

• Animals infected with strains of Trypanosoma brucei and T. rhodesiense exhibited cutaneous hypersensitivity to intradermal administration of antigen. This reactivity was of two types, an Arthus-type, antibody-mediated reaction which reached maximum intensity 4 hr after injection and a delayed-type, cell-mediated reaction which reached maximum intensity 24 hr after injection. This delayed-type hypersensitivity appeared in rabbits not earlier than 3 weeks after onset of infection. It did not occur in animals which received dead organisms. There was a cross-reaction in both types of reactivity between antigens prepared from T. brucei and T. rhodesiense. The delayed-type hypersensitivity was transferred to normal rabbits by intravenous inoculation of washed living cells from the spleen of a rabbit which showed delayed hypersensitivity. Dead cells failed to transfer hypersensitivity. The histological picture of the indurated area was typical of a delayed-type reaction.

authors

• Tizard, Ian

published proceedings

• Infect Immun

author list (cited authors)

• Tizard, I. R., & Soltys, M. A.

citation count

• 25

complete list of authors

• Tizard, IR||Soltys, MA

publication date

• December 1971

publisher

• American Society for Microbiology  Publisher

published in

• Infection and Immunity  Journal

keywords

• Animals
• Antigens
• Cross Reactions
• Hypersensitivity, Delayed
• Injections, Intradermal
• Rabbits
• Skin
• Skin Tests
• Time Factors
• Trypanosoma
• Trypanosoma Brucei Brucei
• Trypanosomiasis

PubMed Central ID

• 5154901

Digital Object Identifier (DOI)

• 10.1128/iai.4.6.674-677.1971

start page

• 674

end page

• 677

volume

• 4

issue

• 6

URL

• http://dx.doi.org/10.1128/iai.4.6.674-677.1971

user-defined tag

• 3 Good Health and Well-Being