Degranulation of sensitised rat peritoneal mast cells in response to antigen, compound 48-80 and polymyxin B. A scanning electron microscope study. Academic Article uri icon


  • The degranulation of mast cells under the influence of compound 48/80, polymyxin B sulphate and specific antigen was studied by scanning electron microscopy. It was observed that granules appeared to leave the cell through a process of exocytosis. In addition, pores appeared on the surface of treated cells. No differences were noted in the morphology of degranulation brought about by the three agents tested. It is concluded that both exocytosis and pore formation are significant mechanisms in mast cell degranulation.

published proceedings

  • Int Arch Allergy Appl Immunol

author list (cited authors)

  • Tizard, I. R., & Holmes, W. L.

citation count

  • 17

complete list of authors

  • Tizard, IR||Holmes, WL

publication date

  • January 1974