Mitogenicity of autolysates of Trypanosoma congolense. Academic Article

abstract

• Autolysates of Trypanosoma congolense, in subcytotoxic amounts, were found to be highly mitogenic in vitro for the spleen cells of normal mice. Significant amounts of [3H]-thymidine were also incorporated by the responding spleen cells of nu/nu (athymic) mice. In contrast, the spleen cells of cyclophosphamide-treated mice were unresponsive. The findings suggest that a potent B-cell-mitogen is generated by the autolysing T. congolense organism.

authors

• Tizard, Ian

published proceedings

• Experientia

author list (cited authors)

• Assoku, R. K., & Tizard, I. R.

citation count

• 23

complete list of authors

• Assoku, RK||Tizard, IR

publication date

• January 1978

publisher

• Springer Nature  Publisher

published in

• Experientia  Journal

keywords

• Animals
• Autolysis
• Cyclophosphamide
• In Vitro Techniques
• Mice
• Mitogens
• Spleen
• Trypanosoma

PubMed Central ID

• 620724

Digital Object Identifier (DOI)

• 10.1007/BF01921943

start page

• 127

end page

• 129

volume

• 34

issue

• 1

URL

• http://dx.doi.org/10.1007/bf01921943