Studies on the generation of biologically active substances by Trypanosoma theileri in vitro.

abstract

• Trypanosoma theileri was grown in bovine primary spleen cell cultures. These organisms were tested for phospholipase activity which was found to be very low, for haemolytic activity which was very weak and for lymphocyte mitogenicity which was found to be absent. High concentrations of T theileri were found to activate bovine complement probably by both the alternate and classical pathways. There was no evidence that these organisms exerted any significant toxic effect in vitro or in vivo. This is compatible with the known low pathogenicity of this species.

authors

• Tizard, Ian

published proceedings

• Res Vet Sci

author list (cited authors)

• Tizard, I. R., Gorski, J., Sheppard, J., Mellors, A., & Hambrey, P.

citation count

• 5

complete list of authors

• Tizard, IR||Gorski, J||Sheppard, J||Mellors, A||Hambrey, P

publication date

• March 1980

publisher

• Elsevier  Publisher

published in

• Research in Veterinary Science  Journal

keywords

• Animals
• Complement System Proteins
• Culture Techniques
• Hemolysis
• Lymphocyte Activation
• Phospholipases
• Trypanosoma

PubMed Central ID

• 7414063

Digital Object Identifier (DOI)

• 10.1016/S0034-5288(18)32742-5

start page

• 178

end page

• 184

volume

• 28

issue

• 2

URL

• http://dx.doi.org/10.1016/s0034-5288(18)32742-5