The biological activities of mannans and related complex carbohydrates. Academic Article

abstract

• Complex polymers containing mannose (mannans) possess significant biological activity when administered to mammals. When given orally, they inhibit cholesterol absorption and induce hypocholesterolemia. If administered by other routes, they bind to mannose-binding proteins and induce macrophage activation and interleukin-1 release, inhibit viral replication, stimulate bone marrow activity, promote wound healing and inhibit tumor growth. This range of activities makes the mannans, potentially important biological-response modifiers and therapeutic agents.

authors

• Tizard, Ian

published proceedings

• Mol Biother

author list (cited authors)

• Tizard, I. R., Carpenter, R. H., McAnalley, B. H., & Kemp, M. C.

citation count

• 88

complete list of authors

• Tizard, IR||Carpenter, RH||McAnalley, BH||Kemp, MC

publication date

• December 1989

published in

• Molecular biotherapy  Journal

keywords

• Animals
• Antineoplastic Agents
• Antiviral Agents
• Bone Marrow
• Humans
• Immune System
• Immunosuppressive Agents
• Intestines
• Lectins, C-Type
• Macrophage Activation
• Mannans
• Mannose Receptor
• Mannose-Binding Lectins
• Neoplasms, Experimental
• Receptors, Cell Surface
• Receptors, Immunologic
• Wound Healing

PubMed Central ID

• 2692629

start page

• 290

end page

• 296

volume

• 1

issue

• 6