Structural and genetic diversity in antibody repertoires from diverse species. Academic Article uri icon

abstract

  • The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody repertoires may enable discovery or engineering of antibodies from these non-human species against difficult or important epitopes.

published proceedings

  • Curr Opin Struct Biol

altmetric score

  • 3

author list (cited authors)

  • de los Rios, M., Criscitiello, M. F., & Smider, V. V.

citation count

  • 51

complete list of authors

  • de los Rios, Miguel||Criscitiello, Michael F||Smider, Vaughn V

publication date

  • August 2015