Role of FGFs in skeletal muscle and limb development Academic Article uri icon


  • Fibroblast growth factors (FGFs) are a family of nine proteins that bind to three distinct types of cell surface molecules: (i) FGF receptor tyrosine kinases (FGFR-1 through FGFR-4); (ii) a cysteine-rich FGF receptor (CFR); and (iii) heparan sulfate proteoglycans (HSPGs). Signaling by FGFs requires participation of at least two of these receptors: the FGFRs and HSPGs form a signaling complex. The length and sulfation pattern of the heparan sulfate chain determines both the activity of the signaling complex and, in part, the ligand specificity for FGFR-1. Thus, the heparan sulfate proteoglycans are likely to play an essential role in signaling. We have recently identified a role for FGF in limb bud development in vivo. In the chick limb bud, ectopic expression of the 18 kDa form of FGF-2 or FGF-2 fused to an artificial signal peptide at its amino terminus causes skeletal duplications. These data, and the observations that FGF-2 is localized to the subjacent mesoderm and the apical ectodermal ridge in the early developing limb, suggest that FGF-2 plays an important role in limb outgrowth. We propose that FGF-2 is an apical ectodermal ridge-derived factor that participates in limb outgrowth and patterning.

author list (cited authors)

  • Olwin, B. B., Arthur, K., Hannon, K., Hein, P., Zhou, Z., Zuber, M. E., ... Fallon, J. F.

citation count

  • 54

complete list of authors

  • Olwin, BB||Arthur, K||Hannon, K||Hein, P||McFall, A||Riley, B||Szebenyi, G||Zhou, Z||Zuber, ME||Rapraeger, AC

publication date

  • September 1994