Lateral-flow particle filtration and separation with multilayer microfluidic channels Academic Article uri icon


  • Separating particles from a suspension and sorting particles into different size ranges are important to many chemical, biological, and bioengineering applications. In this article, a novel lateral-flow particle separation device is presented for continuous particle fractionation from suspensions. This device is based on three-dimensional multilayer poly(dimethylsiloxane) microchannels, which can be fabricated by high-yield and low-cost molding and transfer-bonding techniques. By varying the dimensions of the microchannels in each layer, particles in a suspension can be fractionated into specific layers based on their sizes. Particle separation is successfully achieved in sorting polystyrene microbeads of 1, 10, and 45 m in diameter into different layers. The yield and selectivity of particle separation can be controlled by device geometries such as channel width and length. This novel continuous-flow particle filtration and separation device is expected to find applications in micrototal analysis systems due to its simple fabrication steps, low cost, and capability of particle separation in a deterministic fashion. 2009 American Vacuum Society.

published proceedings


author list (cited authors)

  • Kim, H. C., Park, J., Cho, Y., Park, H., Han, A., & Cheng, X.

citation count

  • 3

complete list of authors

  • Kim, Hyun Chul||Park, Jaewon||Cho, Younghak||Park, Hyunsoo||Han, Arum||Cheng, Xing

publication date

  • December 2009