Haplotype structure and copy number polymorphism of the beta‐defensin 7 genes in diverse chicken breeds
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Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7.
author list (cited authors)
Lee, M. O., Romanov, M. N., Plemyashov, K. V., Dementieva, N. V., Mitrofanova, O. V., Barkova, O. Y., & Womack, J. E.
complete list of authors
Lee, MO||Romanov, MN||Plemyashov, KV||Dementieva, NV||Mitrofanova, OV||Barkova, OY||Womack, JE