Genetic variation and gene conversions within the bovine NK-lysin gene family. Academic Article

abstract

• In contrast to a single copy of the NK-lysin gene in humans and many other mammals, we previously identified a family of four expressed NK-lysin genes arising by tandem duplications on cattle chromosome 11. Here, we report two genetic variants in the bovine NK-lysin complex with potential importance in the bovine innate immune system. The first one is a 9-bp deletion causing a three-amino-acid deletion in the pro-region of the NK1 gene product. The second is a deletion of NK2B in some Holstein cattle, resulting in copy number variation that is in disequilibrium with a SNP from the bovine 770K HD SNP array. We also show evidence for gene conversions within the three new NK2 genes, which at least partially accounts for their high degree of sequence identity.

authors

• Womack, James

published proceedings

• Anim Genet

altmetric score

• 0.25

author list (cited authors)

• Chen, J., Lee, M. O., & Womack, J. E.

citation count

• 5

complete list of authors

• Chen, J||Lee, MO||Womack, JE

publication date

• April 2017

publisher

• Wiley  Publisher

published in

• Animal Genetics  Journal

keywords

• Animals
• Antimicrobial Peptide
• Cattle
• Copy Number Variation
• DNA Copy Number Variations
• Evolution, Molecular
• Gene Conversion
• Genetic Variation
• Indel
• Linkage Disequilibrium
• Polymorphism, Single Nucleotide
• Proteolipids

PubMed Central ID

• 27925267

Digital Object Identifier (DOI)

• 10.1111/age.12521

start page

• 225

end page

• 227

volume

• 48

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1111%2Fage.12521