A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11. Academic Article

abstract

• Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.

authors

• Skow, Loren

published proceedings

• Genomics

author list (cited authors)

• Nadeau, J. H., Berger, F. G., Cox, D. R., Crosby, J. L., Davisson, M. T., Ferrara, D., ... Lalley, P. A.

citation count

• 44

complete list of authors

• Nadeau, JH||Berger, FG||Cox, DR||Crosby, JL||Davisson, MT||Ferrara, D||Fuchs, E||Hart, C||Hunihan, L||Lalley, PA

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Alleles
• Animals
• Blotting, Southern
• Chromosomes
• Cricetinae
• Crosses, Genetic
• Female
• Genes, Homeobox
• Genetic Linkage
• Hybrid Cells
• Keratins
• Male
• Mice
• Multigene Family
• Mutation
• Rats
• Recombination, Genetic

Digital Object Identifier (DOI)

• 10.1016/0888-7543(89)90009-8

start page

• 454

end page

• 462

volume

• 5

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0888-7543%2889%2990009-8