Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals.

abstract

• Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.

authors

• Skow, Loren

published proceedings

• Genomics

altmetric score

• 3

author list (cited authors)

• Skow, L. C., Adkison, L., Womack, J. E., Beamer, W. G., & Taylor, B. A.

citation count

• 40

complete list of authors

• Skow, LC||Adkison, L||Womack, JE||Beamer, WG||Taylor, BA

publication date

• November 1987

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Animals
• Biological Evolution
• Chromosome Mapping
• Crystallins
• Fibronectins
• Genetic Linkage
• Humans
• Isocitrate Dehydrogenase
• Mammals
• Mice
• Mice, Inbred Strains
• Polymorphism, Restriction Fragment Length

PubMed Central ID

• 2895729

Digital Object Identifier (DOI)

• 10.1016/0888-7543(87)90057-7

start page

• 283

end page

• 286

volume

• 1

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0888-7543%2887%2990057-7