How may paths exist from the membrane to the nucleus? - Texas A&M University (TAMU) Scholar

This symposium was organized to examine cell-extracellular matrix interactions and the signals generated by those interactions. The first speaker is Martin Schwartz. He will examine the signal transduction events stimulated by integrin ligation and clustering. The second speaker, Valerie Weaver will build on this work by discussing the effects of blocking cell-matrix interactions on phenotype characteristics of mammary tumor cells. Michael Woodruff and Diane Barber will discuss the down-stream effects of the signal transduction process. Michael Woodruff will concentrate on calcium signaling in tracheal epithelial cells. Diane Barber will discuss cross talk between integrin signaling and GTPase-linked Na-H exchangers. The final speaker of the session is David Nix from Mary Beckerle's laboratory. They have just reported that zyxin, a LIM domain protein, localized in focal adhesions may act as a shuttle protein directly between the membrane and nucleus. In summary, this symposium will not only explore the pathways from the membrane to the nucleus, but will also discuss the influence these interactions have on phenotype.

How may paths exist from the membrane to the nucleus? Academic Article