Regulation of epithelial-mesenchymal transition in palatal fusion. Academic Article

abstract

• During palatal fusion, the midline epithelial seam between the palatal shelves degrades to achieve mesenchymal confluence. Morphological and molecular evidence support the theory that the epithelial-mesenchymal transition is one mechanism that regulates palatal fusion. It appears that transforming growth factor (TGF)-beta signaling plays a role in palatal EMT. TGFbeta3 is the main inducer in palatal fusion and activates both Smad-dependent and -independent signaling pathways, including the key EMT transcription factors, Lef1, Twist, and Snail1, in the MEE prior to the palatal EMT program. The roles and interactions among these transcription factors will be discussed.

authors

• Ruest, Louisbruno
• Svoboda, Kathy

published proceedings

• Exp Biol Med (Maywood)

author list (cited authors)

• Yu, W., Ruest, L., & Svoboda, K.

citation count

• 41

complete list of authors

• Yu, Wenli||Ruest, Louis-Bruno||Svoboda, Kathy KH

publication date

• May 2009

publisher

• SAGE Publications  Publisher

keywords

• Animals
• Epithelium
• Humans
• Lymphoid Enhancer-binding Factor 1
• Mesoderm
• Nuclear Proteins
• Palate
• Signal Transduction
• Smad Proteins
• Snail Family Transcription Factors
• Transcription Factors
• Transforming Growth Factor Beta3
• Twist-Related Protein 1

Digital Object Identifier (DOI)

• 10.3181/0812-MR-365

start page

• 483

end page

• 491

volume

• 234

issue

• 5

URL

• http://dx.doi.org/10.3181/0812-mr-365