Cell-Matrix Interactions and Signal Transduction Book

abstract

• 2015 Elsevier Inc. All rights reserved. In multicellular organisms, cells live in a complex environment composed of other cells and an extracellular matrix (ECM). The ECM is a dynamic three-dimensional (3D) network that actively interacts with cells through ECM receptors. Such interactions are crucial for normal biological processes and wound healing, including cell adhesion, survival, proliferation, migration, differentiation, and new tissue formation. In this chapter, we will focus on cell-matrix interactions and the consequent signal transduction pathways. First, the ECM receptor family will be introduced, including the integrin and non-integrin cell surface receptors. Our current understanding of the interactions of integrins with their ECM ligands and intramembrane proteins that lead to downstream signaling in the cytoplasm will be discussed. In addition, the control of cell-matrix interactions via mechanical forces, matrix morphology, and matrix degradation is summarized. Cellular responses to two- and three-dimensional surfaces will be emphasized in the final section of the chapter.

authors

• Liu, Xiaohua
• Svoboda, Kathy

author list (cited authors)

• Liu, X., Qu, T., Sachar, A., & Svoboda, K.

citation count

• 3

complete list of authors

• Liu, Xiaohua||Qu, Tiejun||Sachar, Ashneet||Svoboda, Kathy KH

publication date

• November 2015

publisher

• Elsevier  Publisher

Digital Object Identifier (DOI)

• 10.1016/B978-0-12-397157-9.00004-7

International Standard Book Number (ISBN) 13

• 978-0-12-397157-9

start page

• 47

end page

• 60

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fb978-0-12-397157-9.00004-7