The extracellular matrix environment in suture morphogenesis and growth. Academic Article

abstract

• Sutures are the major bone growth sites of the craniofacial skeleton and form in response to developmental approximation of and interaction between two opposing osteogenic fronts. Premature obliteration of these craniofacial bone growth sites or craniosynostosis results in compensatory growth at other bone growth sites, with concomitant craniofacial dysmorphology. While much is now known about the growth and transcriptional factor regulation of suture formation and maintenance, little about the nature of the extracellular environment within sutures and their surrounding bones has been described. This review elucidates the nature of the sutural extracellular matrix and its role in mediating suture maintenance and growth through the regulation of cellular and biomechanical signaling.

authors

• Opperman, Lynne

published proceedings

• Cells Tissues Organs

author list (cited authors)

• Opperman, L. A., & Rawlins, J. T.

citation count

• 21

complete list of authors

• Opperman, Lynne A||Rawlins, Joseph T

publication date

• April 2005

publisher

• Karger Publishers  Publisher

published in

• Cells, Tissues, Organs: in vivo, in vitro  Journal

keywords

• Animals
• Biomechanical Phenomena
• Cranial Sutures
• Extracellular Matrix
• Extracellular Matrix Proteins
• Humans
• Mice
• Morphogenesis

PubMed Central ID

• 16612078

Digital Object Identifier (DOI)

• 10.1159/000091374

start page

• 127

end page

• 135

volume

• 181

issue

• 3-4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1159%2F000091374