Regulation of Calvarial Bone Growth by Molecules Involved in the Craniosynostoses Book uri icon


  • The development and growth of the mammalian cranium is choreographed by a complex interplay of dynamic interactions between its constituent bone plates and the sutures that buffer them. These interactions are governed by several families of cytokines and growth factors that act to control osteoblast proliferation, migration and maturation. In this chapter, we discuss 3 of those families whose central roles in bone growth are highlighted by their association with dysregulated growth in craniosynostosis. It is hoped that study of the interplay between these - the ephrins, fibroblast growth factors, and transforming growth factors beta - will reveal molecular targets for future treatment in a clinical setting. Copyright 2011 S. Karger AG, Basel.

author list (cited authors)

  • Benson, M. D., & Opperman, L. A.

citation count

  • 2

complete list of authors

  • Benson, MD||Opperman, LA

publication date

  • December 2011