Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva. Academic Article uri icon


  • UNLABELLED: This study was designed to determine if vacuum-induced suction increased the number of blood vessels in healthy dog gingiva as a prelude to future studies testing vacuum therapy for improving local blood supply and controlling periodontal disease. METHODS: The buccal gingiva of five dogs was treated with subatmospheric pressure for 5 days, with untreated tissues acting as controls. Biopsies were analyzed for vascular endothelial growth factors (VEGF) and blood vessels were counted. RESULTS: VEGF and vessel numbers were elevated in treatment groups compared to controls (P < 0.05). CONCLUSION: A single daily application of subatmospheric pressure might be beneficial for healing damaged or diseased gingival tissues. .

published proceedings

  • Wounds

author list (cited authors)

  • Budinskaya, O. V., Kontogiorgos, E. D., Brownlee, M., Lee, J. S., Budinskiy, R. A., Dechow, P. C., ... Opperman, L. A.

citation count

  • 2

complete list of authors

  • Budinskaya, Oksana V||Kontogiorgos, Elias D||Brownlee, Meredith||Lee, Jennifer S||Budinskiy, Roman A||Dechow, Paul C||Wright, John M||Svoboda, Kathy KH||Opperman, Lynne A

publication date

  • April 2012