Electric field-induced reversible trapping of microtubules along metallic glass microwire electrodes Academic Article uri icon

abstract

  • © 2015 AIP Publishing LLC. Microtubules are among bio-polymers providing vital functions in dynamic cellular processes. Artificial organization of these bio-polymers is a requirement for transferring their native functions into device applications. Using electrophoresis, we achieve an accumulation of microtubules along a metallic glass (Pd42.5Cu30Ni7.5P20) microwire in solution. According to an estimate based on migration velocities of microtubules approaching the wire, the electrophoretic mobility of microtubules is around 10-12 m2/Vs. This value is four orders of magnitude smaller than the typical mobility reported previously. Fluorescence microscopy at the individual-microtubule level shows microtubules aligning along the wire axis during the electric field-induced migration. Casein-treated electrodes are effective to reversibly release trapped microtubules upon removal of the external field. An additional result is the condensation of secondary filamentous structures from oriented microtubules.

altmetric score

  • 1.6

author list (cited authors)

  • Kim, K., Sikora, A., Nakayama, K. S., Umetsu, M., Hwang, W., & Teizer, W.

citation count

  • 2

publication date

  • April 2015