Modulating the microtubule-tau interactions in biomotility systems by altering the chemical environment. Academic Article uri icon


  • Obstacles in microtubule mediated neuronal transport can trigger dementia. We use bio-motility assays, that simulate the neuron chemistry in axonopathy, to screen chemicals, that retain the microtubule dynamics in healthy neuronal activity. Tau protein inhibits microtubule activity and leads to oligomerization. Iron(iii) untangles, whereas mono-sodium-glutamate destabilizes the microtubule oligomer.

published proceedings

  • Integr Biol (Camb)

author list (cited authors)

  • Bhattacharyya, S., Kim, K., Nakazawa, H., Umetsu, M., & Teizer, W.

citation count

  • 4

complete list of authors

  • Bhattacharyya, S||Kim, K||Nakazawa, H||Umetsu, M||Teizer, W

publication date

  • December 2016