Numerical deconvolution using system identification methods. Academic Article uri icon


  • A deconvolution method is presented for use in pharmacokinetic applications involving continuous models and small samples of discrete observations. The method is based on the continuous-time counterpart of discrete-time least squares system identification, well established in control engineering. The same technique, requiring only the solution of a linear regression problem, is used both in system identification and input identification steps. The deconvolution requires no a priori information, since the proposed procedure performs system identification (including optimal selection of model order), selects the form of the input function and calculates its parametric representation and its values at specified time points.

published proceedings

  • J Pharmacokinet Biopharm

author list (cited authors)

  • Vajda, S., Godfrey, K. R., & Valko, P.

citation count

  • 26

complete list of authors

  • Vajda, S||Godfrey, KR||Valko, P

publication date

  • February 1988