Transcription regulation within the circadian clock: the E-box and beyond. Academic Article

abstract

• The circadian oscillator is composed of transcriptional feedback loops in organisms ranging from cyanobacteria to humans. These transcriptional feedback loops are so named because transcriptional regulators accumulate to high levels and then feed back to control their own genes' transcription, thus generating a self-sustaining rhythm in gene expression. In insects and vertebrates, the genes that encode these feedback regulators are remarkably well conserved and function to control not 1 but 2 feedback loops. These feedback loops control rhythmic transcription in opposite phases of the circadian cycle, yet they are interlocked because they share a number of components. In this review, the author will compare transcriptional regulatory mechanisms within the Drosophila and mammalian feedback loops and outline remaining questions concerning transcriptional regulation within and downstream of these feedback loops.

authors

• Hardin, Paul

published proceedings

• J Biol Rhythms

altmetric score

• 9.008

author list (cited authors)

• Hardin, P. E.

citation count

• 118

complete list of authors

• Hardin, Paul E

publication date

• October 2004

publisher

• SAGE Publications  Publisher

published in

• World of Information Business Intelligence Reports. Albania  Journal

keywords

• Animals
• Biological Clocks
• Circadian Rhythm
• Drosophila
• Gene Expression Regulation
• Humans
• Mice
• Models, Biological
• Oscillometry
• Phosphorylation
• Time Factors
• Trans-Activators
• Transcription, Genetic

PubMed Central ID

• 15534316

Digital Object Identifier (DOI)

• 10.1177/0748730404268052

start page

• 348

end page

• 360

volume

• 19

issue

• 5

URL

• http%3A%2F%2Fdx.doi.org%2F10.1177%2F0748730404268052