Transcriptional feedback loop regulation, function, and ontogeny in Drosophila. Conference Paper

abstract

• The Drosophila circadian oscillator is composed of interlocked period/timeless (per/tim) and Clock (Clk) transcriptional feedback loops. These feedback loops drive rhythmic transcription having peaks at dawn and dusk during the daily cycle and function in the brain and a variety of peripheral tissues. To understand how the circadian oscillator keeps time and controls metabolic, physiological, and behavioral rhythms, we must determine how these feedback loops regulate rhythmic transcription, determine the relative importance of the per/tim and Clk feedback loops with regard to circadian oscillator function, and determine how these feedback loops come to be expressed in only certain tissues. Substantial insight into each of these issues has been gained from experiments performed in our lab and others and is summarized here.

authors

• Hardin, Paul

published proceedings

• Cold Spring Harb Symp Quant Biol

author list (cited authors)

• Benito, J., Zheng, H., Ng, F. S., & Hardin, P. E.

citation count

• 21

complete list of authors

• Benito, J||Zheng, H||Ng, FS||Hardin, PE

publication date

• January 2007

publisher

• Cold Spring Harbor Laboratory  Publisher

published in

• Cold Spring Harbor Laboratory: Symposia on Quantitative Biology  Journal

keywords

• Animals
• Basic-Leucine Zipper Transcription Factors
• CLOCK Proteins
• Circadian Rhythm
• Drosophila
• Drosophila Proteins
• Feedback, Physiological
• Gene Expression Regulation
• Genes, Insect
• Models, Biological
• Nuclear Proteins
• Period Circadian Proteins
• Tissue Distribution
• Transcription Factors
• Transcription, Genetic

PubMed Central ID

• 18419302

Digital Object Identifier (DOI)

• 10.1101/sqb.2007.72.009

start page

• 437

end page

• 444

volume

• 72

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1101%2Fsqb.2007.72.009