A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Academic Article uri icon


  • Genes expressed under circadian-clock control are found in organisms ranging from prokaryotes to humans. In Drosophila melanogaster, the period (per) gene, which is required for clock function, is transcribed in a circadian manner. We have identified a circadian transcriptional enhancer within a 69-bp DNA fragment upstream of the per gene. This enhancer drives high-amplitude mRNA cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (PER) dependent. An E-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that PER mediates circadian transcription through other sequences in this fragment.

published proceedings

  • Mol Cell Biol

altmetric score

  • 6

author list (cited authors)

  • Hao, H., Allen, D. L., & Hardin, P. E

citation count

  • 193

complete list of authors

  • Hao, H||Allen, DL||Hardin, PE

publication date

  • July 1997