Circadian Clocks: The Tissue Is the Issue
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The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.
author list (cited authors)
Menet, J. S., & Hardin, P. E.