Circadian Clocks: The Tissue Is the Issue Academic Article uri icon

abstract

  • The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.

altmetric score

  • 0.75

author list (cited authors)

  • Menet, J. S., & Hardin, P. E.

citation count

  • 10

publication date

  • January 2014