RtoA links initial cell type choice to the cell cycle in Dictyostelium. Academic Article uri icon

abstract

  • In Dictyostelium, initial cell type choice is correlated with the cell-cycle phase of the cell at the time of starvation. We have isolated a mutant, ratioA (rtoA), with a defect in this mechanism that results in an abnormally high percentage of prestalk cells. The rtoA gene has been cloned and sequenced and codes for a novel protein. The cell cycle is normal in rtoA. In the wild type, prestalk cells differentiate from those cells in S or early G2 phase at starvation and prespore cells from cells in late G2 or M phase at starvation. In rtoA mutants, both prestalk and prespore cells originate randomly from cells in any phase of the cell cycle at starvation.

author list (cited authors)

  • Wood, S. A., Ammann, R. R., Brock, D. A., Li, L., Spann, T., & Gomer, R. H.

citation count

  • 41

publication date

  • November 1996