A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion. Academic Article

abstract

• A remarkable aspect of Dictyostelium development is that cells form evenly sized groups of approximately 2 x 10(4) cells. A secreted 450 kDa protein complex called counting factor (CF) regulates the number of cells per group. We find that CF regulates group size by repressing cell-cell adhesion. In both experiments and computer simulations, high levels of CF (and thus low adhesion) result in aggregation streams breaking up into small groups, while no CF (and thus high adhesion) results in no stream breakup and large groups. These results suggest that in Dictyostelium and possibly other systems a secreted factor regulating cell-cell adhesion can regulate the size of a group of cells.

authors

• Gomer, Richard

published proceedings

• Mol Cell

author list (cited authors)

• Roisin-Bouffay, C., Jang, W., Caprette, D. R., & Gomer, R. H.

citation count

• 76

complete list of authors

• Roisin-Bouffay, C||Jang, W||Caprette, DR||Gomer, RH

publication date

• January 2000

publisher

• Elsevier  Publisher

published in

• Molecular Cell  Journal

keywords

• Animals
• Cell Adhesion
• Computer Simulation
• Dictyostelium
• Movement
• Protozoan Proteins

Digital Object Identifier (DOI)

• 10.1016/s1097-2765(05)00082-1

start page

• 953

end page

• 959

volume

• 6

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fs1097-2765%2805%2900082-1