N(2)-Substituted D, L-Cycloserine Derivatives
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A select series of N(2)-substituted D,L-cycloserine derivatives were prepared a ndevaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.
author list (cited authors)
KIM, M. G., STRYCH, U., KRAUSE, K., BENEDIK, M., & KOHN, H.