N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. Academic Article uri icon


  • A select series of N(2)-substituted D,L-cycloserine derivatives were prepared a ndevaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.

published proceedings

  • J Antibiot (Tokyo)

altmetric score

  • 6

author list (cited authors)

  • Kim, M. G., Strych, U., Krause, K., Benedik, M., & Kohn, H.

citation count

  • 22

complete list of authors

  • Kim, Myoung Goo||Strych, Ulrich||Krause, Kurt||Benedik, Michael||Kohn, Harold

publication date

  • January 2003