A large cluster of highly expressed genes is dispensable for growth and development in Aspergillus nidulans. Academic Article

abstract

• We investigated the functions of the highly expressed, sporulation-specific SpoC1 genes of Aspergillus nidulans by deleting the entire 38-kb SpoC1 gene cluster. The resultant mutant strain did not differ from the wild type in (1) growth rate, (2) morphology of specialized reproductive structures formed during completion of the asexual or sexual life cycles, (3) sporulation efficiency, (4) spore viability or (5) spore resistance to environmental stress. Thus, deletion of the SpoC1 gene cluster, representing 0.15% of the A. nidulans genome, had no readily detectable phenotypic effects. Implications of this result are discussed in the context of major alterations in gene expression that occur during A. nidulans development.

authors

• Aramayo, Rodolfo

published proceedings

• Genetics

author list (cited authors)

• Aramayo, R., Adams, T. H., & Timberlake, W. E.

citation count

• 83

complete list of authors

• Aramayo, R||Adams, TH||Timberlake, WE

publication date

• May 1989

publisher

• Oxford University Press (OUP)  Publisher

published in

• Genetics  Journal

keywords

• Aspergillus Nidulans
• DNA
• Gene Expression Regulation
• Genes, Fungal
• Multigene Family
• Mutation
• Nucleic Acid Hybridization
• Plasmids
• RNA
• Spores, Fungal

PubMed Central ID

• 2471671

Digital Object Identifier (DOI)

• 10.1093/genetics/122.1.65

start page

• 65

end page

• 71

volume

• 122

issue

• 1

URL

• http://dx.doi.org/10.1093/genetics/122.1.65