Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development.

abstract

• This report describes the identification, cloning, and molecular analysis of Asm-1+ (Ascospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development.

authors

• Aramayo, Rodolfo

published proceedings

• Genetics

altmetric score

• 3

author list (cited authors)

• Aramayo, R., Peleg, Y., Addison, R., & Metzenberg, R.

citation count

• 105

complete list of authors

• Aramayo, R||Peleg, Y||Addison, R||Metzenberg, R

publication date

• November 1996

publisher

• Oxford University Press (OUP)  Publisher

published in

• Genetics  Journal

keywords

• Amino Acid Sequence
• Base Sequence
• Cell Nucleus
• Cloning, Molecular
• DNA, Fungal
• Fungal Proteins
• Gene Deletion
• Gene Expression Regulation, Fungal
• Genes, Regulator
• Molecular Sequence Data
• Neurospora Crassa
• Sequence Homology, Amino Acid
• Transcription Factors
• Transcription, Genetic

PubMed Central ID

• 8913744

Digital Object Identifier (DOI)

• 10.1093/genetics/144.3.991

start page

• 991

end page

• 1003

volume

• 144

issue

• 3

URL

• https://doi.org/10.1093/genetics/144.3.991