Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development. Academic Article uri icon


  • This report describes the identification, cloning, and molecular analysis of Asm-1+ (Ascospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development.

published proceedings

  • Genetics

altmetric score

  • 3

author list (cited authors)

  • Aramayo, R., Peleg, Y., Addison, R., & Metzenberg, R.

citation count

  • 102

complete list of authors

  • Aramayo, R||Peleg, Y||Addison, R||Metzenberg, R

publication date

  • November 1996