Unpaired genes do not silence their paired neighbors. Academic Article uri icon


  • During meiotic chromosome pairing, a loop of unpaired DNA induces the silencing of all paired and unpaired homologous DNA via meiotic silencing, an RNA-mediated post-transcriptional gene-silencing mechanism. To test the effect of unpaired DNA on adjacent genes, we constructed strains containing the DNA of a transformation marker integrated immediately downstream of the Ascospore maturation-1 ( Asm-1) gene and tested whether this unpaired DNA silences asm-1(+). We conclude that unpaired downstream DNA has no effect on Asm-1 expression during meiosis or ascospore development, which suggests that the silencing signal produced by unpaired DNA does not propagate onto adjacent paired regions.

published proceedings

  • Curr Genet

author list (cited authors)

  • Kutil, B. L., Seong, K., & Aramayo, R.

citation count

  • 11

complete list of authors

  • Kutil, Brandi L||Seong, Kye-Yong||Aramayo, Rodolfo

publication date

  • September 2003