Validation of the M. D. Anderson Symptom Inventory multiple myeloma module. Academic Article uri icon

abstract

  • BACKGROUND: The symptom burden associated with multiple myeloma (MM) is often severe. Presently, no instrument comprehensively assesses disease-related and treatment-related symptoms in patients with MM. We sought to validate a module of the M. D. Anderson Symptom Inventory (MDASI) developed specifically for patients with MM (MDASI-MM). METHODS: The MDASI-MM was developed with clinician input, cognitive debriefing, and literature review, and administered to 132 patients undergoing induction chemotherapy or stem cell transplantation. We demonstrated the MDASI-MM's reliability (Cronbach values); criterion validity (item and subscale correlations between the MDASI-MM and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the EORTC MM module (QLQ-MY20)), and construct validity (differences between groups by performance status). Ratings from transplant patients were examined to demonstrate the MDASI-MM's sensitivity in detecting the acute worsening of symptoms post-transplantation. RESULTS: The MDASI-MM demonstrated excellent correlations with subscales of the 2 EORTC instruments, strong ability to distinguish clinically different patient groups, high sensitivity in detecting change in patients' performance status, and high reliability. Cognitive debriefing confirmed that the MDASI-MM encompasses the breadth of symptoms relevant to patients with MM. CONCLUSION: The MDASI-MM is a valid, reliable, comprehensive-yet-concise tool that is recommended as a uniform symptom assessment instrument for patients with MM.

published proceedings

  • J Hematol Oncol

altmetric score

  • 0.5

author list (cited authors)

  • Jones, D., Vichaya, E. G., Wang, X. S., Williams, L. A., Shah, N. D., Thomas, S. K., ... Mendoza, T. R.

citation count

  • 35

complete list of authors

  • Jones, Desiree||Vichaya, Elisabeth G||Wang, Xin Shelley||Williams, Loretta A||Shah, Nina D||Thomas, Sheeba K||Johnson, Valen E||Champlin, Richard E||Cleeland, Charles S||Mendoza, Tito R

publication date

  • January 2013